Aberrations of DNA methylation in cancer

DNA methylation is a chromatin modification that plays an important role in the epigenetic regulation of gene expression. Changes patterns are characteristic many malignant neoplasms. occurred by methyltransferases (DNMTs), while demethylation mediated TET family proteins. Mutations and changes expression profile these enzymes lead to hypo- hypermethylation have strong impact on carcinogenesis. In this review, we considered key aspects mechanisms demethylation, also analyzed proteins pathogenesis various neoplasms.During preparation used following biomedical literature information bases: Scopus (504), PubMed (553), Web Science (1568), eLibrary (190). To obtain full-text documents, electronic resources Central (PMC), Direct, Research Gate, CyberLeninka were used. analyze mutational regulatory enzymes, cBioportal portal (https://www.cbioportal.org / ), data from The AACR Project GENIE Consortium (https://www.mycancergenome.org COSMIC, Clinvar, Cancer Genome Atlas (TCGA).